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Two common definitions of the spatially local rate of kinetic energy cascade at some scale$$\ell$$in turbulent flows are (i) the cubic velocity difference term appearing in the ‘scale-integrated local Kolmogorov–Hill’ equation (structure-function approach), and (ii) the subfilter-scale energy flux term in the transport equation for subgrid-scale kinetic energy (filtering approach). We perform a comparative study of both quantities based on direct numerical simulation data of isotropic turbulence at Taylor-scale Reynolds number 1250. While in the past observations of negative subfilter-scale energy flux (backscatter) have led to debates regarding interpretation and relevance of such observations, we argue that the interpretation of the local structure-function-based cascade rate definition is unambiguous since it arises from a divergence term in scale space. Conditional averaging is used to explore the relationship between the local cascade rate and the local filtered viscous dissipation rate as well as filtered velocity gradient tensor properties such as its invariants. We find statistically robust evidence of inverse cascade when both the large-scale rotation rate is strong and the large-scale strain rate is weak. Even stronger net inverse cascading is observed in the ‘vortex compression’$$R>0$$,$$Q>0$$quadrant, where$$R$$and$$Q$$are velocity gradient invariants. Qualitatively similar but quantitatively much weaker trends are observed for the conditionally averaged subfilter-scale energy flux. Flow visualizations show consistent trends, namely that spatially, the inverse cascade events appear to be located within large-scale vortices, specifically in subregions when$$R$$is large.